KeraVanta's formulation heritage is supported by third-party ex vivo skin model testing performed using Genoskin's InflammaSkin platform, a psoriasis-like human skin model designed to reproduce key features of Th1/Th17-driven skin inflammation. Nirvanta seed oil formulations were topically applied and evaluated against untreated InflammaSkin controls, a seed oil vehicle, NativeSkin controls, and betamethasone as a positive control. Cytokine release was evaluated at Day 3 and Day 7 using multiplex cytokine analysis, with IL-22 ELISA and histologic review used to confirm model responsiveness and skin integrity.

Study design

Study design

Human ex vivo InflammaSkin model; controls included NativeSkin, untreated InflammaSkin, seed oil vehicle, and betamethasone positive control.
Measured signals

Measured signals

Cytokine release at Day 3 and Day 7. Key pathway signals included IFN-gamma, TNF-alpha, IL-22, IL-17A, IL-10, IP-10, MIP-1beta, GM-CSF, and VEGF.
Professional interpretation

Professional interpretation

The data are best described as ex vivo cytokine modulation supporting a cosmetic skin-support rationale, not a drug or clinical efficacy claim.

Observed Testing Highlights


The untreated InflammaSkin model showed strong inflammatory activation, including Th1-associated markers IFN-gamma and TNF-alpha and Th17-associated markers IL-22 and IL-17A. The report observed that the seed oil vehicle reduced several cytokines, including GM-CSF, IFN-gamma, IL-10, and IL-22, suggesting the oil base contributed activity rather than serving as an inert carrier. By Day 7, the study noted targeted modulation associated with active components, including TNF-alpha, IFN-gamma, IL-10, IP-10, MIP-1beta, and IL-17A Gen.B.

Product Testing: Why Testing on Human Skin Matters

Reconstructed human skin models (T-Skin(TM)) emerged in the 1980s as an ethical and more accurate alternative to animal testing. Designed to provide a reliable platform for research, these models are now a mainstay in cosmetic research, helping to assess the safety and efficacy of topical products. But how accurately do these models represent real human skin? And can they fulfill the needs of dermatology and cosmetic product development? [No Humans were harmed in the making of these products.

What's in Human Skin vs. T-Skin(TM)?

HUMAN SKIN CONTAINS

  • Presence of subcutaneous tissue
  • Robustness to support injection
  • Skin appendages
  • Sweat glands
  • Sebaceous glands
  • Hair follicles
  • Peripheral nerves
  • Blood circulation
  • Melanocytes and melanogenesis
  • The presence of functional skin resident immune cells
  • Skin barrier Function* Microbiome

Professional positioning: The data are best described as ex vivo cytokine modulation supporting a cosmetic skin-support rationale. Additional donor
testing and human-use studies would be needed to confirm clinical outcomes. This section is written for professional cosmetic/educational review and
should not be interpreted as a clinical efficacy claim or drug claim.